US-British Trio Win Nobel Medicine Prize For Hepatitis C Discovery

Americans Harvey Alter and Charles Rice together with Briton Michael Houghton won the Nobel Medicine Prize on Monday for the discovery of the Hepatitis C virus, paving the way for a cure, the Nobel jury said.

The three were honoured for their “decisive contribution to the fight against blood-borne hepatitis, a major global health problem that causes cirrhosis and liver cancer in people around the world,” the jury said.

The World Health Organization estimates there are around 70 million Hepatitis C infections globally, causing around 400,000 deaths each year. It is characterized by poor appetite, vomiting, fatigue and jaundice.

The three were honoured for their "decisive contribution to the fight against blood-borne hepatitis The three were honoured for their “decisive contribution to the fight against blood-borne hepatitis” Photo: AFP / Jonathan NACKSTRAND

Thanks to the trio’s discoveries, highly sensitive blood tests for the virus are now available and these have “essentially eliminated post-transfusion hepatitis in many parts of the world, greatly improving global health”, the Nobel committee said.

Their discoveries allowed the rapid development of antiviral drugs directed at Hepatitis C.

“For the first time in history, the disease can now be cured, raising hopes of eradicating Hepatitis C virus from the world population,” the jury said.

Alter, 85, told the Nobel Foundation he was stunned to receive an early-morning call from the committee, saying he didn’t answer the first two times.

The World Health Organization estimates there to be around 70 million Hepatitis C infections globally, causing around 400,000 deaths each year The World Health Organization estimates there to be around 70 million Hepatitis C infections globally, causing around 400,000 deaths each year Photo: AFP / Jonathan NACKSTRAND

“The third time I got up angrily to answer it… and it was Stockholm,” he said, adding that he was “in shock.”

“To see so many people get cured, and nobody getting post-transfusion hepatitis, that’s astounding (and) nothing I’ve ever thought would happen,” he said.

Prior to the trio’s work, the discovery of the Hepatitis A and B viruses had been critical steps forward — the discovery of Hepatitis B won the Nobel Medicine Prize in 1976 — but the majority of blood-borne hepatitis cases remained unexplained.

IMAGESAmericans Harvey Alter and Charles Rice together with Briton Michael Houghton won the Nobel Medicine Prize for the discovery of the Hepatitis C virus, the Nobel jury says. IMAGESAmericans Harvey Alter and Charles Rice together with Briton Michael Houghton won the Nobel Medicine Prize for the discovery of the Hepatitis C virus, the Nobel jury says. Photo: AFPTV / Tom LITTLE

The discovery of Hepatitis C virus revealed the cause of the remaining cases of chronic hepatitis, and “made possible blood tests and new medicines that have saved millions of lives”, the Nobel committee said.

Alter was credited for his pioneering work studying the occurrence of hepatitis in patients who had received blood transfusions, determining that their illness was neither Hepatitis A or B.

Houghton built on Alter’s work to isolate the genetic sequence of the new virus.

Rice, 68, subsequently completed the puzzle by using genetic engineering to prove that it was the new strain alone — Hepatitis C — that was causing patients to get sick.

The winners of the Nobel prize for medicine 2015-2020 The winners of the Nobel prize for medicine 2015-2020 Photo: AFP / Paz PIZARRO

The trio will share the prize sum of 10 million Swedish kronor (about $1.1 million, 950,000 euros).

In 2013, Houghton reportedly declined Canada’s Gairdner International Award because two of his key collaborators who worked with him at pharmaceutical group Chiron Corp were not included.

Houghton, Alter and Rice would normally receive their prize from King Carl XVI Gustaf at a formal ceremony in Stockholm on December 10, the anniversary of the 1896 death of scientist Alfred Nobel who created the prizes in his will.

But the in-person ceremony has been cancelled this year due to the pandemic and replaced with a televised ceremony showing the laureates receiving their awards in their home countries.

Their award comes as the hunt for a coronavirus vaccine has put the global spotlight on their field.

“The pandemic is a big crisis for mankind, but it illustrates how important science is,” Nobel Foundation head Lars Heikensten said.

No prizes were expected to be awarded this year directly linked to the coronavirus, as Nobel prize-winning research usually takes many years to be verified.

But Nobel medicine committee chair Patrik Ernfors said Monday’s prize was “relatively easy to relate to today’s situation”.

“The first thing you need to do is to identify the causing virus, and once that has been done, that is in itself the starting point for the development of drugs to treat the disease and also to develop vaccines against the disorder. So the actual viral discovery itself is a critical moment.”

The 2020 Nobel season continues Tuesday with the physics prize, with astrophysicists Shep Doeleman of the US and Germany’s Heino Falcke seen as possible winners for work that led to the first directly observed image of a black hole in April 2019.

American mathematician Peter Shor who paved the way for today’s research on quantum computers, or France’s Alain Aspect for his work on quantum entanglement, have also been mentioned.

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