Two biologic therapies showed promise in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (EGPA) in a retrospective European study.
Among 63 patients who were treated with rituximab (Rituxan), remission or partial responses at 1 year were observed in 49% and 24% of patients, respectively, reported Benjamin Terrier, MD, PhD, of Université Paris Descartes in Paris, and colleagues.
In addition, as shown in the team’s study online in Arthritis & Rheumatology, among the 51 patients who had received mepolizumab (Nucala), remission or partial response at 1 year was seen in 78% and 10%, respectively. Remission or partial response was seen in only 15% and 33% of the 33 patients treated with omalizumab (Xolair).
EGPA is a small-vessel vasculitis characterized by asthma, sinusitis, and blood and tissue eosinophilia, with a subset of patients also positive for antineutrophil cytoplasmic antibodies (ANCA). Traditional therapy has relied on glucocorticoids and conventional