Tennessee football is without a senior defensive lineman Saturday.

Darel Middleton posted on Twitter he will not play at South Carolina “due to health issues.”

“I want be playing today,” Middleton wrote. “But back next week after a couple check ups. Ready to go. Im on the edge of my seat tonight!”

No. 21 Tennessee opens its season against South Carolina at 7:30 p.m. ET Saturday on SEC Network.

The 6-foot-7, 305-pound Middleton had 28