Oct. 6 (UPI) — Newly captured video of cells moving through narrow channels promises to help scientists better understand the mechanics of cell migration.
The observations, described Tuesday in the journal Biophysical Journal, could offer insights into how cancer metastasizes, or spreads from one area of the body to another.
“Our results describe how cells can migrate and deform through confined spaces, providing potentially new ways to envision cell motility in small blood capillaries in vivo,” senior study author Daniel Riveline, researcher at the University of Strasbourg in France, said in a news release.
Until now, cell motility has mostly been studied on 2D surfaces, but in the body, migrating cells travel through 3D environs. Most often, cells move through blood vessels. For the study, researchers developed vessel-like, micro-fabricated channels.
Some channels were open, confined by just three walls, while others were closer, confined by four walls. Researchers micro-fabricated both