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Could Type 1 Diabetes Begin in Utero?

October 13, 2020

Infants might develop type 1 diabetes in the first 6 months of life and seems to be unrelated to known genetic risk factors; rather, it appears linked to low birth weight, say UK researchers.

They believe the discovery could mean the disease starts in utero.

Others are skeptical, however.

The team studied 166 infants with diabetes diagnosed before 6 months of age and compared them to babies with the more common neonatal diabetes and children diagnosed with type 1 diabetes at older ages.

The combination of high type 1 diabetes genetic risk score (T1D-GRS), presence of islet-specific autoantibodies, and evidence of a rapid loss of insulin secretion all suggest that the infants had type 1 diabetes.

And notably, they all had a lower median birth weight than international reference standards.

“This study proves that type 1 diabetes can present in the first few months of life, and in a tiny

Health Coverage Takes Big Hit With Pandemic-Related Job Cuts | Health News

October 13, 2020

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By Robert Preidt, HealthDay Reporter

(HealthDay)

TUESDAY, Oct. 13, 2020 (HealthDay News) — Up to 7.7 million U.S. workers lost jobs with employer-sponsored health insurance during the coronavirus pandemic, and 6.9 million of their dependents also lost coverage, a new study finds.

Workers in manufacturing, retail, accommodation and food services were especially hard-hit by job losses, but unequally impacted by losses in insurance coverage.

Manufacturing accounted for 12% of unemployed workers in June. But because the sector has one of the highest rates of employer-sponsored coverage at 66%, it accounted for a bigger loss of jobs with insurance (18%) and 19% of potential coverage loss when dependents are included.

Nearly 3.3 million workers in accommodation and food services had lost their jobs as of June — 30% of the industry’s workforce. But only 25% of workers in the sector had employer-sponsored insurance before the pandemic. Seven percent lost jobs with

CytRx Highlights Use of Licensed Drug Aldoxorubicin in ImmunityBio’s Expanded Phase 2 Study of Pancreatic Cancer Treatment

October 13, 2020

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Third-Line Cohort Added to Phase 2 Pancreatic Cancer Trial for Combination Immunotherapy That Includes Aldoxorubicin, ImmunityBio’s N-803 and NantKwest’s PD-L1 t-haNK

Three Trial Sites in California and South Dakota Will Initially Enroll 298 Patients Across the Cohorts, With 40 Patients Already Enrolled or Being Evaluated

CytRx Corporation (OTCQB:CYTR) (“CytRx” or the “Company”), a specialized biopharmaceutical company focused on research and development for the oncology and neurodegenerative disease categories, today highlighted that ImmunityBio, Inc. and NantKwest, Inc. (collectively, the “Companies”) have announced the addition of a third cohort to their ongoing Phase 2 study of a novel combination immunotherapy – which includes CytRx’s licensed drug aldoxorubicin – for locally advanced or metastatic pancreatic cancer (QUILT-88). According to the Companies, the third cohort will enable pancreatic cancer patients who have failed all approved standards of care to participate in the study.

As previously noted in CytRx’s October 7, 2020 press release regarding

Johnson & Johnson Pauses COVID-19 Vaccine Clinical Trials over Participant’s ‘Unexplained Illness’

October 13, 2020

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Johnson & Johnson has paused its late stage clinical trials for a COVID-19 vaccine because of an “unexplained” illness in one of the participants, the company said Monday.

It said in a news release that the trial was paused while the study’s independent Data Safety Monitoring Board conducted a review and evaluation of the participant’s condition.

“Adverse events — illnesses, accidents, etc. — even those that are serious, are an expected part of any clinical study, especially large studies.”

The company noted the “significant distinction” between a study pause and a regulatory hold, explaining that a pause is not unexpected in vaccine trials.

“A study pause, in which recruitment or dosing is paused by the study sponsor, is a standard component of a clinical trial protocol,” the statement said.

Johnson & Johnson’s coronavirus vaccine became the fourth to begin Phase 3 trials in the United States last month and

How Teens Handled Quarantine – The Atlantic

October 13, 2020

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Some of our most interesting findings had to do with teens’ use of technology. When the pandemic hit and quarantine began, teens were unable to spend time with friends or fellow students face-to-face. Electronic communication became the primary way teens could interact with people outside of their families. Given that screen time, especially time spent using social media, has been associated with mental-health issues in teens, we wanted to understand how technology affected their mental health in quarantine.

To our surprise, teens’ technology use did not appear to increase dramatically during the pandemic when compared with 2018. Teens in quarantine were spending more time videochatting with friends and watching TV, videos, and movies on an electronic device. But they spent less time gaming, texting, and using social media.

We were surprised that social media, which is more connective, decreased, while passively watching television and videos increased during that same time.

Notable Labs Announces Addition of Thomas Bock to Board of Directors

October 13, 2020

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Notable, which is redefining cancer treatment by taking a functional approach to precision oncology in hematological cancers, today announced the addition of Dr. Thomas A. Bock to its board of directors.

Bock is a recognized life science leader who built four entrepreneurial organizations that created major impact for both patients and investors, achieving leadership in their fields. He successfully spearheaded new medical paradigms and fast-growing markets such as cancer precision medicine, ultra-rare disorders and cancer prevention.

“We are delighted to welcome Thomas Bock to Notable’s board of directors,” said Laurie Heilmann, Notable CEO. “Thomas’ wealth of experience leading worldwide medical divisions at top-tier pharma organizations such as Novartis, Celgene and Alexion will be of great value to Notable. Thomas developed and commercialized six lifesaving, paradigm-changing blockbuster medicines in cancer, ultra-rare disorders and inflammation. Thomas brings tremendous industry knowledge and experience, which will be instrumental in navigating and supporting Notable’s path

How coronavirus’s genetic code can help control outbreaks

October 13, 2020

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The six British patients seemed to have little in common besides this: Each was dealing with kidney failure, and each had tested positive for the coronavirus.

They were among scores of virus-stricken people showing up at Addenbrooke’s Hospital in Cambridge in the early weeks of April. Had they lived in the United States instead of the United Kingdom, the link that allowed the contagion to spread among them might have slipped by unnoticed.

But the U.K. had done something in the early days of the pandemic that the United States and many other nations had not. It funded a national push to repeatedly decode the coronavirus genome as it made its way across the country. The process reveals tiny, otherwise invisible changes in the virus’s genetic code, leaving a fingerprint that gives scientists valuable glimpses into how the disease is spreading. It’s a cutting-edge technique that

Gossamer Bio Announces Topline Results for Phase 2 Trials of Oral GB001 in Asthma and Chronic Rhinosinusitis

October 13, 2020

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– Primary endpoint of asthma worsening not met in LEDA Study, however consistent numeric reductions ranging from 32-35% observed across all three GB001 groups –

– Statistically significant improvements in key secondary endpoint of time to first asthma worsening of 28% and 30% observed for 20 mg and 60 mg doses of GB001, respectively; 23% improvement observed in 40 mg group –

– TITAN Study in chronic rhinosinusitis did not meet primary or secondary endpoints –

– Gossamer to hold webcast to discuss trial results at 8:00 am EDT –

Gossamer Bio, Inc. (Nasdaq: GOSS), a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology, today announced topline results from its Phase 2b LEDA trial in patients with moderate-to-severe eosinophilic asthma and its Phase 2 TITAN trial in patients with chronic rhinosinusitis.

“While we did not achieve statistical significance

J&J pauses coronavirus vaccine trials due to unexplained illness

October 13, 2020

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(Reuters) – Johnson & Johnson JNJ.N has paused clinical trials of its coronavirus vaccine candidate due to an unexplained illness in a study participant, delaying one of the highest profile efforts to contain the global pandemic.

The move comes around a month after AstraZeneca AZN.L also suspended trials of its experimental coronavirus vaccine – which uses a similar technology – due to a participant falling ill.

J&J said on Monday the illness was being reviewed by an independent data and safety monitoring board as well as the U.S. group’s clinical and safety physicians.

The company, which reports quarterly financial results on Tuesday morning, said such pauses are normal in big trials, which can include tens of thousands of people.

It added the voluntary “study pause” in giving doses of the vaccine candidate was different from a “regulatory hold” imposed by health authorities.

AstraZeneca last month paused late-stage trials of its

Rising Covid-19 cases and an uptick in hospitalizations may be the start of a predicted surge, officials warn

October 13, 2020

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With 33 states reporting a rise in new Covid-19 cases and a nationwide uptick in hospitalizations, local officials worry this could be the beginning of the coming surge experts have warned about.

© CHANDAN KHANNA/AFP/Getty Images
A medic prepares to transfer a patient on a stretcher from an ambulance outside of Emergency at Coral Gables Hospital where Coronavirus patients are treated in Coral Gables near Miami, on July 30, 2020. – Florida has emerged as a major new epicenter of the US battle against the disease, with confirmed cases recently surpassing New York and now second only to California. The state toll has leapt over the past week and more than 6,500 people have died from the disease there, according to health officials. More than 460,000 people have been infected with the virus in Florida, which has a population of 21 million, and a quarter of the state’s cases are

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Category: Health

Could Type 1 Diabetes Begin in Utero?

Health Coverage Takes Big Hit With Pandemic-Related Job Cuts | Health News

CytRx Highlights Use of Licensed Drug Aldoxorubicin in ImmunityBio’s Expanded Phase 2 Study of Pancreatic Cancer Treatment

Johnson & Johnson Pauses COVID-19 Vaccine Clinical Trials over Participant’s ‘Unexplained Illness’

How Teens Handled Quarantine – The Atlantic

Notable Labs Announces Addition of Thomas Bock to Board of Directors

How coronavirus’s genetic code can help control outbreaks

Gossamer Bio Announces Topline Results for Phase 2 Trials of Oral GB001 in Asthma and Chronic Rhinosinusitis

J&J pauses coronavirus vaccine trials due to unexplained illness

Rising Covid-19 cases and an uptick in hospitalizations may be the start of a predicted surge, officials warn